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Gymnema Extract

Gymnema sylvestre is commonly known as gurmar. 


Phytochemicals, such as triterpenoid saponins (gymnemic acid and gymnema saponins) and polypeptide, gurmarin, are the main active constituents of gymnema.

  • Impacts Glucose Absorption & Insulin Release

    Gymnema affects both the absorption of glucose and the release of insulin to benefit glucose balance.​

  • Has Antioxidant Properties

    Due to the presence of flavonoids, cinnamic acid, folic acid, ascorbic acid etc., gymnema may also have antioxidant properties that counter the inflammation and oxidative stress associated with diabetes and its complications.​

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Mechanism of Actions

  • Inhibits of glucose absorption from intestine by binding to Na+/glucose cotransporter (SGLT1) in intestine​
  • Restores functional mass of pancreatic β cells and protects β cells against oxidative damage ​
  • Stimulates glucose-induced insulin secretion by recruiting GLUT2 signaling​
  • Endorses fatty acid oxidation and reciprocates insulin resistance in the liver, skeletal muscle and adipose tissue through PPAR-δ activation​

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LITERATURE

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