OleAct

OleAct™ Olive Extract

High in Olive Triterpenes
Contains olive triterpenes such as maslinic and oleanolic acid, together with phenolic compounds like oleuropein.
Lower Basal Glycemia
It helps to lower basal glycemia, protecting against insulin resistance. It improves postprandial insulin release and sensitivity.
High Antioxidant Potency
Olive extract has strong antioxidant activity and inhibits the formation of advanced glycation end (AGE) products, implicated in the pathogenesis of diabetic complications.

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Improves the insulin signaling transduction in hepatocytes, through enhancing the phosphorylation of Akt and inhibiting the phosphorylation of mTOR
Suppresses gluconeogenesis in the liver mediated by the Akt/ FoxO1 axis
Delays the hydrolysis and absorption of monosaccharides by the inhibition of α-glucosidase activity
Inhibits glycogen phosphorylase (GP)
Enhances antioxidant defenses via activation of JNK and ERK
Inhibits oxidative stress‐induced hepatic insulin resistance and gluconeogenesis
Exerts mitochondria‐protecting effect
Preserves β cells functionality, by promoting β cells survival and proliferation
Inhibits AGEs formation in non insulin-sensitive tissues
Improves insulin sensitivity in peripheral tissues

Modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting
glycogen phosphorylase
Elevates the tyrosine auto-phosphorylation level of IRβ and the phosphorylation levels of Akt and GSK3β
Reduces the activity of carbohydrate hydrolases and decreases the expression of glucose transporter proteins in the intestine
Reduces the expression of GLUTI and GLUT2 in the kidney
Increases insulin sensitivity by activating AMPK/SIRT1 signaling pathway
Reduces the oxidative stress and inflammation. Reduces the deposition of AGEs

Reduces intestinal glucose absorption by inhibiting GLUT2 transporters
Improves insulin sensitivity in skeletal muscles and the liver
Improves pancreatic β-cell responsivenes
Increases in peripheral intake of glucose and insulin secretion induced by glucose
Counteracts oxidative stress-mediated down-regulation of incretins, which are hormones involved in regulating insulin secretion and glucose metabolism
Inhibits dipeptidyl peptidase-4 (DPP-4) activity, an enzyme involved in the degradation of incretins
Enhances the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion in response to glucose
Prevents diabetes complications associated with oxidative stress