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Patented peptide sequence: mcIRBP-19 Plant Insulin

The unique peptides of Insumate® have been decoded and found to be a small molecule peptide composed of 19 amino acids with the molecular weight of 2,162 daltons, endowing it with a high affinity to insulin receptor even after passing through stomach acid. This natural small molecule peptide can effectively reduce fasting blood glucose, stabilize glycosylated hemoglobin, and induce protein synthesis, which interferes with the signaling cascade of fat synthesis and reaches the effects of increasing muscle mass and reducing fat formation.

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Mechanism of Action

Insumate®, an insulin-like protein, can interact with insulin receptors on cells and activate the corresponding signal transduction. It opens GLUT4 channels which facilitates the increase of glucose transportation into cells, which is beneficial for modulating blood sugar level, decreasing fat accumulation and increasing muscle transformation.

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Clinical Studies

Clinical Study 1 

  • 29 subjects with uncontrolled diabetes.
  • Dosage of Insumate is 300mg two times a day, before lunch and dinner and not to take them within 30 min of other medications.
  • Study duration: 3 months

Results reveal that Insumate® mcIRBP-19 can significantlyimprove the blood glucose and HbA1c levels. HbA1c decreased by 0.5% on average.

Source: Yang YS et al., Food Nutr Res. 2022 Jan 3:66.

Clinical Study 2 

  • 142 subjects with uncontrolled diabetes.
  • Dosage of Insumate is 300mg two times a day, before lunch and dinner and not to take them within 30 min of other medications.
  • Study duration: 3 months

Results reveal that Insumate® mcIRBP-19 can significantlyimprove the blood glucose and HbA1c levels. Besides, this study showed a significant decrease in triglyceride (TG) and a significant increase in high-density lipoprotein cholesterol (HDL-C).

Source: Hsu PK et al., Nutrients. 2020 Apr 28;12(5):1252.

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LITERATURE

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